![]() ![]() Reported to be weakly or moderately adherent, capable of translocating over surfaces thanks to twitching motility, and invasive in and a metalloprotease A-B exotoxin that induces apoptosis in Virulenceįactors of this pathogen include a polysaccharide capsular layer All rights reserved.Įspecially in Mediterranean countries and Japan. piscicida (Phdp), the causativeĪgent of photobacteriosis, is an important pathogen in marineĪquaculture that affects many different fish species worldwide,ġ050-4648/© 2017 Elsevier Ltd. Include photobacteriosis as one of the most important diseases Outbreaks affecting this species impose limits to the industry and Solea senegalensis is an important fish species in marine aquaculture in the south of Europe due to its high price, market demandĪnd high growth potential of the industry. The development of novel antimicrobial or prophylactic agents in the treatment and prevention of Proteins induced during in vivo growth of Phdp represent promising targets for Synthesis of the siderophore piscibactin have been identified as antigens induced in Phdp during Inosi ne-50 -monophosphate dehydrogenase, serine hydroxy methyltransferase andĪlanyl-tRNA synthethase, involved in aminoacid and nucleotide metabolism, the protein with antioxidantĪctivity alkyl hydroperoxide reductase and a non-ribosomal peptide synthetase responsible for the In addition, five proteins were reactive against adsorbed sera, indicating their in vivo senegalensis infection and are immunogenic for That proteins encoded are expressed by Phdp during S. senegalensis specimens and 18 clones were positive, indicating An expression library from Phdp was assayedĪgainst pooled sera from convalescent S. Only expressed or up-regulated in infected S. In the present work, in vivo induced antigen technology (IVIAT) has been used to search for Phdp genes The case of pathogens, identification of genes with up-regulated expression in vivo compared to in vitroĬonditions might give an insight into the genes relevant to the bacterial virulence. Invading a host, sense in vivo environment and adapt by changing the expression of specific proteins. ![]() Senegalensis, an important fish species for aquaculture in the south of Europe.īacteria express different repertoires of proteins in response to environmental conditions and when Pathogen in marine aquaculture that affects many different fish species worldwide, including Solea piscicida (Phdp), the causative agent of photobacteriosis, is an important laga, Departamento de Microbiología, Campus de Teatinos s/n, 29071 Ma Use of in vivo induced technology to identify antigens expressed by Results obtained give insight into Phdp virulence strategies and contribute to the identification of promising targets for the control of photobacteriosis.Fish
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